In vitro effect of larval stages of Ascaris lumbricoides on human blood clotting.

نویسندگان

  • N Malla
  • B A Sofi
  • N K Ganguly
  • R C Mahajan
چکیده

The effects of larval stages of Ascaris lumbricoides on human blood clotting was studied in vitro. Extracts and excretory/secretory products of third-stage larvae (L3) and late third-stage larvae (LL3) cultured from ova obtained from infected patients were analysed for anti-coagulant activity. Prothrombin time (PT) was prolonged by the addition of either whole extract of L3/LL3 or ES products of L3/LL3 as compared to controls. Partial thromboplastin time with kaolin (PTTK) was also prolonged on the addition of either extracts of ES products of L3/LL3. The prolongation of PTTK was significantly higher with extracts/ES products of L3 when compared to the extracts/ES products of LL3 (p less than 0.005). Thrombin time (TT) was prolonged by extracts of L3/LL3 and their ES products.

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عنوان ژورنال:
  • Journal of helminthology

دوره 65 2  شماره 

صفحات  -

تاریخ انتشار 1991